ISDA: 9SQY

Deposition Date 2025-09-23

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9SQY

Keywords:

HYDROLASE

Title:

Cryo-EM structure of the ARISC(E33A)-RAP80:K63-Ub7 complex (Composite map)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.92 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lys-63-specific deubiquitinas
Gene (Uniprot):BRCC3
Chain IDs:O (auth: A), P (auth: B)
Chain Length:316
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46736 Pfam ID:PF01398, PF18110 EC:3.4.19.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BRCA1-A complex subunit Abrax
Gene (Uniprot):ABRAXAS1
Chain IDs:A (auth: D), N (auth: C)
Chain Length:446
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q6UWZ7 Pfam ID:PF21125

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BRISC and BRCA1-A complex mem
Gene (Uniprot):BABAM2
Chain IDs:B (auth: E), C (auth: F)
Chain Length:385
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NXR7 Pfam ID:PF06113

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BRISC and BRCA1-A complex mem
Gene (Uniprot):BABAM1
Chain IDs:D (auth: G), E (auth: H)
Chain Length:329
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NWV8

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BRCA1-A complex subunit RAP80
Gene (Uniprot):UIMC1
Chain IDs:F (auth: I), G (auth: J)
Chain Length:724
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q96RL1 Pfam ID:PF18282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):UBC
Chain IDs:H (auth: K), I (auth: L), J (auth: M), K (auth: N), L (auth: O), M (auth: P)
Chain Length:76
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:P0CG48 Pfam ID:PF00240

Ligand Molecules

Primary Citation

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex

Foglizzo, M, Datta, A, Degtjarik, O, Perera, H, Liburd, J, Sykora, U.M, Ganji, R.S, Wildsmith, G, Chandler, F, Campbell, L.J, Calabrese, A.N, Greenberg, R.A, Zeqiraj, E.Show

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Primary Citation of related structures

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