ISDA: 9SQP

Deposition Date 2025-09-23

Release Date 2026-08-12

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9SQP

Keywords:

IMMUNE SYSTEM

Title:

Structure of a disulfide-bridged complex between HLA-A*02:01-K127N/Y84C and ERp57/tapasin-K16C - State 3

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3), Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Gene (Uniprot):HLA-A
Mutagens:Y84C, K127N
Chain IDs:D (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9TQB6

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Mutagens:T5C
Chain IDs:A (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61769 Pfam ID:PF07654

Polymer Type:polypeptide(L)
Molecule:LYS-ILE-LEU-GLY-PHE-VAL-NFA;
Chain IDs:E (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tapasin
Gene (Uniprot):TAPBP
Mutagens:K16C, G304C
Chain IDs:B (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O15533 Pfam ID:PF07654

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein disulfide-isomerase A
Gene (Uniprot):PDIA3
Mutagens:C60A
Chain IDs:C (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P30101 Pfam ID:PF00085, PF13848 EC:5.3.4.1

Ligand Molecules

Primary Citation

Dynamic states of an MHC class I molecule during peptide exchange.

Mitlehner, A, Pasos-Trejo, A.S, Becker, M, Lan, H, Berg, L, Hilal, T, Loll, B, Kuropka, B, Clementi, C, Freund, C.Show

Nat Commun 17 ? ? (2026)

PMID: 42722689 DOI: 10.1038/s41467-026-77731-6

Primary Citation of related structures

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