ISDA: 9SQO

Deposition Date 2025-09-23

Release Date 2026-08-12

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9SQO

Keywords:

IMMUNE SYSTEM

Title:

Structure of a disulfide-bridged complex between HLA-A*02:01-K127N/Y84C and ERp57/tapasin-K16C - State 2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3), Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:MHC class I antigen
Mutagens:Y84C, K127N
Chain IDs:D (auth: A)
Chain Length:301
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Mutagens:T5C
Chain IDs:A (auth: B)
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:LYS-ILE-LEU-GLY-PHE-VAL-NFA,
Chain IDs:E (auth: C)
Chain Length:7
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Tapasin
Mutagens:K16C, G304C
Chain IDs:B (auth: D)
Chain Length:398
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Protein disulfide-isomerase A
Mutagens:C60A
Chain IDs:C (auth: E)
Chain Length:481
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Dynamic states of an MHC class I molecule upon peptide release

Mitlehner, A, Pasos-Trejo, A.S, Becker, M, Hilal, T, Loll, B, Kuropka, B, Clementi, C, Freund, C.Show

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Primary Citation of related structures

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