ISDA: 9SNU

Deposition Date 2025-09-11

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9SNU

Keywords:

TRANSFERASE

Title:

TKD of human Muscle Specific Kinase (MuSK) S752D mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.62 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

I 4

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Muscle, skeletal receptor tyr
Gene (Uniprot):MUSK
Mutagens:S752D
Chain IDs:A
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O15146 Pfam ID:PF07714 EC:2.7.10.1

Primary Citation

An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation.

Promer, J.J, Murphy, J.W, Lemmon, M.A, Tsutsui, Y, Herbst, R.Show

Biochem.J. 483 1221 1235 (2026)

PMID: 42240394 DOI: 10.1042/BCJ20260159

Primary Citation of related structures

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