ISDA: 9SNB

Deposition Date 2025-09-10

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9SNB

Keywords:

LYASE

Title:

human carbonic anhydrase II in complex with 4-(2-fluoro-4-sulfamoylphenyl)-N-(4-fluorophenyl)piperazine-1-carboxamide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.19

R-Value Work:

0.16

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carbonic anhydrase 2
Gene (Uniprot):CA2
Chain IDs:A (auth: AAA)
Chain Length:260
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P00918 Pfam ID:PF00194 EC:4.2.1.1

Ligand Molecules

A1JOU

EDO

GOL

Primary Citation

Targeting Human Carbonic Anhydrases with Novel Piperazine and Homopiperazine Benzenesulfonamides to Alleviate Paclitaxel-Induced Peripheral Neuropathy.

Micheli, L, Angeli, A, Di Cesare Mannelli, L, Ghelardini, C, Ferraroni, M, Barons, R, Zalubovskis, R, Zara, S, Carradori, S, Supuran, C.T.Show

J.Med.Chem. 68 25485 25504 (2025)

PMID: 41307493 DOI: 10.1021/acs.jmedchem.5c02626

Primary Citation of related structures

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