9SME image
Deposition Date 2025-09-07
Release Date 2026-08-12
Last Version Date 2026-08-12
Entry Detail
PDB ID:
9SME
Keywords:
Title:
Crystal structure of CD73 in complex with JMS04-14, a pyrimidine-based nucleoside bisphosphonate inhibitor, in the closed state and in crystal form III
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.55 Å
R-Value Free:
0.28
R-Value Work:
0.25
R-Value Observed:
0.25
Space Group:
P 21 21 2
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:5'-nucleotidase
Chain IDs:A, B
Chain Length:538
Number of Molecules:2
Biological Source:Homo sapiens
Primary Citation
Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors.
Angew.Chem.Int.Ed.Engl. 65 e22758 e22758 (2026)
PMID: 41834421 DOI: 10.1002/anie.202522758
Primary Citation of related structures
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