ISDA: 9SDR

Deposition Date 2025-08-14

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

9SDR

Keywords:

LYASE

Title:

CryoEM structure of human 20S proteasome in complex with proteasome inhibitor Carmaphycin B

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens environmental sample

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.78 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA6
Chain IDs:A, O
Chain Length:246
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P60900

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA2
Chain IDs:B, P
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25787 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA4
Chain IDs:C, Q
Chain Length:261
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25789 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA7
Chain IDs:K (auth: D), Y (auth: Z)
Chain Length:248
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:O14818

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA5
Chain IDs:D (auth: E), R
Chain Length:241
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28066 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA1
Chain IDs:E (auth: F), S
Chain Length:263
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25786

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):PSMA3
Chain IDs:F (auth: G), T
Chain Length:255
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25788 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB6
Chain IDs:L (auth: H), Z (auth: a)
Chain Length:205
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28072 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB7
Chain IDs:M (auth: I), AA (auth: b)
Chain Length:234
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q99436 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB3
Chain IDs:G (auth: J), U (auth: V)
Chain Length:204
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49720 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB2
Chain IDs:H (auth: K), V (auth: W)
Chain Length:201
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49721 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB5
Chain IDs:N (auth: L), BA (auth: c)
Chain Length:200
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28074 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB1
Chain IDs:I (auth: M), W (auth: X)
Chain Length:213
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P20618 EC:3.4.25.1

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):PSMB4
Chain IDs:J (auth: N), X (auth: Y)
Chain Length:219
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P28070 EC:3.4.25.1

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Carmaphycin B, bound form
Chain IDs:CA (auth: U), DA (auth: d), EA (auth: e), FA (auth: f), GA (auth: g), HA (auth: h)
Chain Length:3
Number of Molecules:6
Biological Source:synthetic construct

Ligand Molecules