ISDA: 9S3I

Deposition Date 2025-07-24

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9S3I

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of the human tumor necrosis factor receptor 1 extracellular domain at 1.64A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.64 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 41 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor recepto
Gene (Uniprot):TNFRSF1A
Chain IDs:A, B
Chain Length:164
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P19438 Pfam ID:PF00020

Ligand Molecules

PO4

Primary Citation

Discovery of ligands for the TNFR1 extracellular domain using fragment-based drug discovery

Chedotal, H, Povlsen, K, Narayanan, D, Gotfredsen, C, Gajhede, M, Bach, A, Clausen, M.Show

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Primary Citation of related structures

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