ISDA: 9S3I

Deposition Date 2025-07-24

Release Date 2026-07-01

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9S3I

Keywords:

SIGNALING PROTEIN

Title:

Crystal structure of the human tumor necrosis factor receptor 1 extracellular domain at 1.64A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.64 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Tumor necrosis factor recepto
Chain IDs:A, B
Chain Length:164
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

PO4

Primary Citation

Discovery of Ligands for the TNFR1 Extracellular Domain Using Fragment-Based Drug Discovery.

Chedotal, H, Povlsen, K, Narayanan, D, Gotfredsen, C.H, Gajhede, M, Bach, A, Clausen, M.H.Show

Chemmedchem 21 e70365 e70365 (2026)

PMID: 42399717 DOI: 10.1002/cmdc.70365

Primary Citation of related structures

Feedback Form