9S2J image
Deposition Date 2025-07-21
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9S2J
Keywords:
PEPTIDE BINDING PROTEIN
Title:
Ternary structure of 14-3-3s, CRAF S257L NS mutant phosphopeptide (pS259) and compound 78 (1084378)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.50 Å
R-Value Free:
0.20
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
C 2 2 21
9S2J validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Gene (Uniprot):SFN
Chain IDs:A
Chain Length:236
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P31947 Pfam ID:PF00244
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RAF proto-oncogene serine/thr
Gene (Uniprot):RAF1
Mutagens:S257L
Chain IDs:B (auth: P)
Chain Length:11
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P04049 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP B SER modified residue
Ligand Molecules
CL
MG
WQN
Primary Citation
Restoring the 14-3-3/CRAF regulatory interaction in Noonan Syndrome using molecular glues
To Be Published ? ? ? (?)
Primary Citation of related structures
9S2J
Feedback Form
Name
Email
Institute
Feedback