ISDA: 9S28

Deposition Date 2025-07-21

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9S28

Keywords:

VIRAL PROTEIN

Title:

MVV STC intasome in complex with LEDGF

Biological Source:

Source Organism(s):

Visna/maedi virus EV1 KV1772 (Taxon ID: 36374)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 2169971)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Gag-Pol polyprotein
Gene (Uniprot):pol
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Chain Length:281
Number of Molecules:16
Biological Source:Visna/maedi virus EV1 KV1772

UniProt ID:P35956

Polymer Type:polydeoxyribonucleotide
Molecule:DNA EV392
Chain IDs:AA (auth: T), BA (auth: U)
Chain Length:32
Number of Molecules:2
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA EV306
Chain IDs:CA (auth: W), EA (auth: Y)
Chain Length:29
Number of Molecules:2
Biological Source:synthetic construct

Polymer Type:polydeoxyribonucleotide
Molecule:DNA EV391
Chain IDs:DA (auth: X), FA (auth: Z)
Chain Length:65
Number of Molecules:2
Biological Source:synthetic construct

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:PC4 and SFRS1-interacting pro
Gene (Uniprot):PSIP1
Chain IDs:Q (auth: a), R (auth: b), S (auth: c), T (auth: d), U (auth: e), V (auth: g), W (auth: h), X (auth: i), Y (auth: j), Z (auth: k)
Chain Length:281
Number of Molecules:10
Biological Source:Homo sapiens

UniProt ID:O75475 Pfam ID:PF00855, PF11467

Ligand Molecules

Primary Citation

Core nucleosomes are refractive for lentiviral integration

Hope, J, Punch, E.K, Cook, N.J, Singer, M.R, Joshi, D, Singh, P.K, Nans, A, Engelman, A.N, Cherepanov, P.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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