ISDA: 9RPV

Deposition Date 2025-06-25

Release Date 2025-12-10

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9RPV

Keywords:

RIBOSOME

Title:

Structure of the ZAK-bound human disome

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.35 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:mRNA of the collided 80S
Chain IDs:A (auth: A4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:mRNA of the stalled 80S
Chain IDs:B (auth: A5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:P/E tRNA on the collided 80S
Chain IDs:C (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:P-site tRNA of the stalled 80
Chain IDs:D (auth: B5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:A/P tRNA on the collided 80S
Chain IDs:E (auth: D4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Endothelial differentiation-r
Gene (Uniprot):EDF1
Chain IDs:F (auth: E4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60869 Pfam ID:PF08523, PF01381

Polymer Type:polyribonucleotide
Molecule:E-site tRNA of the stalled 80
Chain IDs:G (auth: E5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:28S rRNA of the collided 80S
Chain IDs:H (auth: L5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:5S rRNA
Chain IDs:I (auth: L7), BB (auth: M7)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:5.8S rRNA of the collided 80S
Chain IDs:J (auth: L8)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L8
Gene (Uniprot):RPL8
Chain IDs:K (auth: LA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62917 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Gene (Uniprot):RPL3
Chain IDs:L (auth: LB)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P39023 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L4
Gene (Uniprot):RPL4
Chain IDs:M (auth: LC), FB (auth: MC)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P36578 Pfam ID:PF00573, PF14374

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L5
Gene (Uniprot):RPL5
Chain IDs:N (auth: LD), GB (auth: MD)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46777 Pfam ID:PF17144, PF14204

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL6
Chain IDs:O (auth: LE), HB (auth: ME)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q02878 Pfam ID:PF03868, PF01159

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL7
Chain IDs:P (auth: LF), IB (auth: MF)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P18124 Pfam ID:PF08079, PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L7a
Gene (Uniprot):RPL7A
Chain IDs:Q (auth: LG), JB (auth: MG)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62424 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L9
Gene (Uniprot):RPL9, RPL9P7, RPL9P8, RPL9P9
Chain IDs:R (auth: LH), KB (auth: MH)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P32969 Pfam ID:PF00347

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein uL16-like
Gene (Uniprot):RPL10L
Chain IDs:S (auth: LI)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96L21 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L11
Gene (Uniprot):RPL11
Chain IDs:T (auth: LJ), MB (auth: MJ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62913 Pfam ID:PF00281, PF00673

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL13
Chain IDs:U (auth: LL), NB (auth: ML)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P26373 Pfam ID:PF01294

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L14
Gene (Uniprot):RPL14
Chain IDs:V (auth: LM), OB (auth: MM)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P50914 Pfam ID:PF01929

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L15
Gene (Uniprot):RPL15
Chain IDs:W (auth: LN), PB (auth: MN)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61313 Pfam ID:PF00827

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L13a
Gene (Uniprot):RPL13A
Chain IDs:X (auth: LO), QB (auth: MO)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P40429 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L17
Gene (Uniprot):RPL17
Chain IDs:Y (auth: LP), RB (auth: MP)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P18621 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L18
Gene (Uniprot):RPL18
Chain IDs:Z (auth: LQ), SB (auth: MQ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q07020 Pfam ID:PF17135

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L19
Gene (Uniprot):RPL19
Chain IDs:AA (auth: LR), TB (auth: MR)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P84098 Pfam ID:PF01280, PF25476

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L18a
Gene (Uniprot):RPL18A
Chain IDs:BA (auth: LS), UB (auth: MS)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q02543 Pfam ID:PF01775

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L21
Gene (Uniprot):RPL21
Chain IDs:CA (auth: LT), VB (auth: MT)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46778 Pfam ID:PF01157

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L22
Gene (Uniprot):RPL22
Chain IDs:DA (auth: LU), WB (auth: MU)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P35268 Pfam ID:PF01776

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L23
Gene (Uniprot):RPL23
Chain IDs:EA (auth: LV), XB (auth: MV)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62829 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L24
Gene (Uniprot):RPL24
Chain IDs:FA (auth: LW), YB (auth: MW)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P83731 Pfam ID:PF01246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L23a
Gene (Uniprot):RPL23A
Chain IDs:GA (auth: LX), ZB (auth: MX)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62750 Pfam ID:PF03939, PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L26
Gene (Uniprot):RPL26
Chain IDs:HA (auth: LY), AC (auth: MY)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61254 Pfam ID:PF16906, PF00467

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27
Gene (Uniprot):RPL27
Chain IDs:IA (auth: LZ), BC (auth: MZ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61353 Pfam ID:PF00467, PF01777

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L27a
Gene (Uniprot):RPL27A
Chain IDs:JA (auth: La)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P46776 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L29
Gene (Uniprot):RPL29
Chain IDs:KA (auth: Lb)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P47914 Pfam ID:PF01779

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L30
Gene (Uniprot):RPL30
Chain IDs:LA (auth: Lc), EC (auth: Mc)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62888 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L31
Gene (Uniprot):RPL31
Chain IDs:MA (auth: Ld), FC (auth: Md)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62899 Pfam ID:PF01198

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L32
Gene (Uniprot):RPL32
Chain IDs:NA (auth: Le), GC (auth: Me)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62910 Pfam ID:PF01655

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35a
Gene (Uniprot):RPL35A
Chain IDs:OA (auth: Lf), HC (auth: Mf)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P18077 Pfam ID:PF01247

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L34
Gene (Uniprot):RPL34
Chain IDs:PA (auth: Lg), IC (auth: Mg)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49207 Pfam ID:PF01199

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L35
Gene (Uniprot):RPL35
Chain IDs:QA (auth: Lh), JC (auth: Mh)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P42766 Pfam ID:PF00831

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36
Gene (Uniprot):RPL36
Chain IDs:RA (auth: Li), KC (auth: Mi)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9Y3U8 Pfam ID:PF01158

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL37
Chain IDs:SA (auth: Lj), LC (auth: Mj)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61927 Pfam ID:PF01907

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L38
Gene (Uniprot):RPL38
Chain IDs:TA (auth: Lk), MC (auth: Mk)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P63173 Pfam ID:PF01781

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L39
Gene (Uniprot):RPL39
Chain IDs:UA (auth: Ll), NC (auth: Ml)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62891 Pfam ID:PF00832

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-60S ribosomal prote
Gene (Uniprot):UBA52
Chain IDs:VA (auth: Lm)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62987 Pfam ID:PF00240, PF01020

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L41
Gene (Uniprot):RPL41
Chain IDs:WA (auth: Ln), PC (auth: Mn)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62945 Pfam ID:PF05162

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L36a
Gene (Uniprot):RPL36A
Chain IDs:XA (auth: Lo)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P83881 Pfam ID:PF00935

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L37a
Gene (Uniprot):RPL37A
Chain IDs:YA (auth: Lp), RC (auth: Mp)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61513 Pfam ID:PF01780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L28
Gene (Uniprot):RPL28
Chain IDs:ZA (auth: Lr)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P46779 Pfam ID:PF01778

Polymer Type:polyribonucleotide
Molecule:28S rRNA of the stalled 80S
Chain IDs:AB (auth: M5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:5.8S rRNA of the stalled 80S
Chain IDs:CB (auth: M8)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL8
Chain IDs:DB (auth: MA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62917 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL3
Chain IDs:EB (auth: MB)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P39023 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L10
Gene (Uniprot):RPL10
Chain IDs:LB (auth: MI)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P27635 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL27A
Chain IDs:CC (auth: Ma)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P46776 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL29
Chain IDs:DC (auth: Mb)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P47914 Pfam ID:PF01779

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-ribosomal protein e
Gene (Uniprot):UBA52
Chain IDs:OC (auth: Mm)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62987 Pfam ID:PF00240, PF01020

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL36A
Chain IDs:QC (auth: Mo)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P83881 Pfam ID:PF00935

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):RPL28
Chain IDs:SC (auth: Mr)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P46779 Pfam ID:PF01778

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L10a
Gene (Uniprot):RPL10A
Chain IDs:TC (auth: Ms)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62906 Pfam ID:PF00687

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitogen-activated protein kin
Gene (Uniprot):MAP3K20
Chain IDs:UC (auth: N1), VC (auth: N2)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NYL2 Pfam ID:PF07714, PF00536, PF07647 EC:2.7.11.25

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPSA
Chain IDs:WC (auth: RA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P08865 Pfam ID:PF00318, PF16122

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3a
Gene (Uniprot):RPS3A
Chain IDs:XC (auth: RB), GE (auth: SB)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P61247 Pfam ID:PF01015

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S2
Gene (Uniprot):RPS2
Chain IDs:YC (auth: RC), HE (auth: SC)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P15880 Pfam ID:PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S3
Gene (Uniprot):RPS3
Chain IDs:ZC (auth: RD), IE (auth: SD)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P23396 Pfam ID:PF07650, PF00189 EC:4.2.99.18

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS4X
Chain IDs:AD (auth: RE), JE (auth: SE)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62701 Pfam ID:PF08071, PF00900, PF00467, PF16121

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S5
Gene (Uniprot):RPS5
Chain IDs:BD (auth: RF), KE (auth: SF)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46782 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S6
Gene (Uniprot):RPS6
Chain IDs:CD (auth: RG), LE (auth: SG)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62753 Pfam ID:PF01092

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S7
Gene (Uniprot):RPS7
Chain IDs:DD (auth: RH), ME (auth: SH)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62081 Pfam ID:PF01251

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):RPS8
Chain IDs:ED (auth: RI), NE (auth: SI)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62241 Pfam ID:PF01201

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S9
Gene (Uniprot):RPS9
Chain IDs:FD (auth: RJ), OE (auth: SJ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46781 Pfam ID:PF00163, PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S10
Gene (Uniprot):RPS10
Chain IDs:GD (auth: RK), PE (auth: SK)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P46783 Pfam ID:PF03501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S11
Gene (Uniprot):RPS11
Chain IDs:HD (auth: RL), QE (auth: SL)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62280 Pfam ID:PF16205, PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S12
Gene (Uniprot):RPS12
Chain IDs:ID (auth: RM), JF (auth: Sf)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P25398 Pfam ID:PF01248

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S13
Gene (Uniprot):RPS13
Chain IDs:JD (auth: RN), RE (auth: SN)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62277 Pfam ID:PF08069, PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S14
Gene (Uniprot):RPS14
Chain IDs:KD (auth: RO), SE (auth: SO)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62263 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15
Gene (Uniprot):RPS15
Chain IDs:LD (auth: RP), TE (auth: SP)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62841 Pfam ID:PF00203

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S16
Gene (Uniprot):RPS16
Chain IDs:MD (auth: RQ), UE (auth: SQ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62249 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S17
Gene (Uniprot):RPS17
Chain IDs:ND (auth: RR), VE (auth: SR)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P08708 Pfam ID:PF00833

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S18
Gene (Uniprot):RPS18
Chain IDs:OD (auth: RS), WE (auth: SS)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62269 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S19
Gene (Uniprot):RPS19
Chain IDs:PD (auth: RT), XE (auth: ST)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P39019 Pfam ID:PF01090

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S20
Gene (Uniprot):RPS20
Chain IDs:QD (auth: RU), YE (auth: SU)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P60866 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):RPS21
Chain IDs:RD (auth: RV)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63220 Pfam ID:PF01249

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S15a
Gene (Uniprot):RPS15A
Chain IDs:SD (auth: RW), AF (auth: SW)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62244 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S23
Gene (Uniprot):RPS23
Chain IDs:TD (auth: RX), BF (auth: SX)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62266 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S24
Gene (Uniprot):RPS24
Chain IDs:UD (auth: RY), CF (auth: SY)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62847 Pfam ID:PF01282

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S25
Gene (Uniprot):RPS25
Chain IDs:VD (auth: RZ), DF (auth: SZ)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62851 Pfam ID:PF03297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S26
Gene (Uniprot):RPS26
Chain IDs:WD (auth: Ra), EF (auth: Sa)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62854 Pfam ID:PF01283

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S27
Gene (Uniprot):RPS27
Chain IDs:XD (auth: Rb), FF (auth: Sb)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P42677 Pfam ID:PF01667

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S28
Gene (Uniprot):RPS28
Chain IDs:YD (auth: Rc), GF (auth: Sc)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62857 Pfam ID:PF01200

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S29
Gene (Uniprot):RPS29
Chain IDs:ZD (auth: Rd), HF (auth: Sd)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62273 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like FUBI-ribosomal
Gene (Uniprot):FAU
Chain IDs:AE (auth: Re), IF (auth: Se)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62861 Pfam ID:PF00240, PF04758

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):RPS27A
Chain IDs:BE (auth: Rf), LF (auth: sh)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62979 Pfam ID:PF00240, PF01599

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Receptor of activated protein
Gene (Uniprot):RACK1
Chain IDs:CE (auth: Rg), KF (auth: Sg)
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P63244 Pfam ID:PF00400

Polymer Type:polyribonucleotide
Molecule:18S rRNA of the collided 80S
Chain IDs:DE (auth: S2)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:18S rRNA of the stalled 80S
Chain IDs:EE (auth: S3)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein SA
Gene (Uniprot):RPSA
Chain IDs:FE (auth: SA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P08865 Pfam ID:PF00318, PF16122

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S21
Gene (Uniprot):RPS21
Chain IDs:ZE (auth: SV)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63220 Pfam ID:PF01249

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details
HIC	EB	HIS	modified residue
M3L	OC	LYS	modified residue
MLZ	DC	LYS	modified residue
V5N	DB	HIS	modified residue

Ligand Molecules

ANM

Primary Citation

ZAK activation at the collided ribosome.

Huso, V.L, Niu, S, Catipovic, M.A, Saba, J.A, Denk, T, Park, E, Cheng, J, Berninghausen, O, Becker, T, Green, R, Beckmann, R.Show

Nature 649 1051 1060 (2026)

PMID: 41261136 DOI: 10.1038/s41586-025-09772-8

Abstact

Ribosome collisions activate the ribotoxic stress response mediated by the MAP3K ZAK, which in turn regulates cell-fate consequences through downstream phosphorylation of the MAPKs p38 and JNK1. Despite the critical role of ZAK during cellular stress, a mechanistic and structural understanding of ZAK-ribosome interactions and how these lead to activation remain elusive. Here we combine biochemistry and cryo-electron microscopy to discover distinct ZAK-ribosome interactions required for constitutive recruitment and for activation. We find that upon induction of ribosome collisions, interactions between ZAK and the ribosomal protein RACK1 enable its activation by dimerization of its SAM domains at the collision interface. Furthermore, we discover how this process is negatively regulated by the ribosome-binding protein SERBP1 to prevent constitutive ZAK activation. Characterization of novel SAM variants as well as a known pathogenic variant of the SAM domain of ZAK supports a key role of the SAM domain in regulating kinase activity on and off the ribosome, with some mutants bypassing the ribosome requirement for ZAK activation. Collectively, our data provide a mechanistic blueprint of the kinase activity of ZAK at the collided ribosome interface.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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