ISDA: 9RKH

Deposition Date 2025-06-13

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9RKH

Keywords:

MEMBRANE PROTEIN

Title:

Dark structure of beta-2 Adrenergic receptor with photoazolol in Dark state recorded at LCLS

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Enterobacteria phage T4 (Taxon ID: 10665)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.21

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2 adrenergic receptor,En
Gene (Uniprot):E, ADRB2
Chain IDs:A
Chain Length:442
Number of Molecules:1
Biological Source:Homo sapiens, Enterobacteria phage T4

UniProt ID:P07550,P00720 Pfam ID:PF00001, PF00959 EC:3.2.1.17

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
YCM	A	CYS	modified residue

Ligand Molecules

12P

A1JHU

CLR

EDO

GOL

OLC

PLM

SO4

Primary Citation

Structural Mechanism of an Efficacy Photoswitch Targeting the beta 2 -adrenergic Receptor.

Stipp, R, Bertrand, Q, Trabuco, M, Duran-Corbera, A, Ignazzitto, M.T, Glover, H, Stierli, F, Catena, J, Carrillo, M, Hartmann, S, Seidel, H.P, Mulder, M, Mason, T, Kondo, Y, Wranik, M, Appleby, M, Sager, C, Sierra, R, Gate, G, Schleissner, P, Cheng, X, Weinert, T, Cheng, R, Mous, S, Beale, J.H, Kepa, M, Llebaria, A, Hennig, M, Rovira, X, Standfuss, J.Show

Angew. Chem. Int. Ed. Engl. ? e17995 e17995 (2026)

PMID: 41848496 DOI: 10.1002/anie.202517995

Primary Citation of related structures

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