ISDA: 9R9M

Deposition Date 2025-05-20

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9R9M

Keywords:

DNA BINDING PROTEIN

Title:

Crystal Structure of human MLH1 C-terminal domain with cyclic peptide (2S)-N-[(6S,9S,12S,15S,18S,26aR)-12-(4-aminobutyl)-18-benzyl-21-(2-carbamoylethyl)-9-(hydroxymethyl)- 15-[(4-hydroxyphenyl)methyl]-1,7,10,13,16,19,22-heptaoxo-hexacosahydropyrrolo[2,1-c]1,4,7,10,13,16,19-heptaazacyclotetracosan-6-yl]-2-[(2S)-2-acetamidopropanamido]-3-methylbutanamide

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.28 Å

R-Value Free:

0.22

R-Value Work:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA mismatch repair protein M
Gene (Uniprot):MLH1
Chain IDs:A, B
Chain Length:267
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P40692 Pfam ID:PF16413

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclic peptide 2
Chain IDs:D (auth: C)
Chain Length:9
Number of Molecules:1
Biological Source:synthetic construct

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclic peptide 1
Chain IDs:C (auth: I)
Chain Length:10
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules