ISDA: 9P51

Deposition Date 2025-06-17

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9P51

Keywords:

DNA BINDING PROTEIN

Title:

Crystal structure of MLH1-CTD with CHDI-00915848

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.25 Å

R-Value Free:

0.21

R-Value Work:

0.19

Space Group:

P 21 21 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA mismatch repair protein M
Gene (Uniprot):MLH1
Chain IDs:A, B
Chain Length:257
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P40692 Pfam ID:PF16413

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CYS-GLN-ALA-VAL-ARG-SER-LYS-T
Chain IDs:C, D
Chain Length:11
Number of Molecules:2
Biological Source:Homo sapiens

Primary Citation

Cyclic Peptide Inhibitors of the MLH1-MSH3 Interaction as a Potential Therapeutic Strategy for Huntington's Disease

Haque, T.S, Orvieto, F, Tomaselli, S, Turcano, L, De Simone, D, Francone, A, Micaelli, M, Movetti, S, Piacenti, V, Gambini, L, Alli, C, Fodale, V, Bianchi, E, Toniatti, C, Kawahara, D, Ghosh, S, Koszelak-Rosenblum, M, Zhu, G, Kintzel, S, Williams, D, Larocque, J, Thieulin-Pardo, G, Thomsen, M, Dominguez, C, Iyer, R.R, Finley, M, Felsenfeld, D, Boudet, J, Monteagudo, E, Vogt, T.F, Prasad, B.C.Show

Chemrxiv 2026 ? ? (?)

DOI: 10.26434/chemrxiv.15000289/v2

Primary Citation of related structures

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