9R8V image
Deposition Date 2025-05-17
Release Date 2026-05-27
Last Version Date 2026-05-27
Entry Detail
PDB ID:
9R8V
Keywords:
SPLICING
Title:
Cryo-EM structure of the human pre-Bact-OTS complex (whole map)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
8.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9R8V validation report missing
Macromolecular Entities
Polymer Type:polyribonucleotide
Molecule:U2 snRNA
Chain IDs:C (auth: 2)
Chain Length:188
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPD1
Chain IDs:X (auth: 21), SA (auth: 51)
Chain Length:119
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62314 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPD2
Chain IDs:Q (auth: 22), TA (auth: 52)
Chain Length:118
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62316 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPD3
Chain IDs:U (auth: 23), UA (auth: 53)
Chain Length:126
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62318 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U2 small nuclear ribonucleopr
Gene (Uniprot):SNRPA1
Chain IDs:Y (auth: 2A)
Chain Length:255
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P09661 Pfam ID:PF14580
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U2 small nuclear ribonucleopr
Gene (Uniprot):SNRPB2
Chain IDs:R (auth: 2B)
Chain Length:225
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P08579 Pfam ID:PF00076
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPB
Chain IDs:T (auth: 2b), RA (auth: 5b)
Chain Length:240
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P14678 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPE
Chain IDs:W (auth: 2e), VA (auth: 5e)
Chain Length:92
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62304 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPF
Chain IDs:S (auth: 2f), WA (auth: 5f)
Chain Length:86
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62306 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small nuclear ribonucleoprote
Gene (Uniprot):SNRPG
Chain IDs:V (auth: 2g), XA (auth: 5g)
Chain Length:76
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:P62308 Pfam ID:PF01423
Polymer Type:polyribonucleotide
Molecule:U5 snRNA
Chain IDs:F (auth: 5)
Chain Length:117
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:PHD finger-like domain-contai
Gene (Uniprot):PHF5A
Chain IDs:KB (auth: 5A)
Chain Length:110
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q7RTV0 Pfam ID:PF03660
Polymer Type:polyribonucleotide
Molecule:U6 snRNA
Chain IDs:D (auth: 6)
Chain Length:106
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM2
Chain IDs:YA (auth: 62)
Chain Length:95
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y333 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM3
Chain IDs:ZA (auth: 63)
Chain Length:102
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62310 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM4
Chain IDs:AB (auth: 64)
Chain Length:139
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y4Z0 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM5
Chain IDs:BB (auth: 65)
Chain Length:91
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y4Y9 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM6
Chain IDs:CB (auth: 66)
Chain Length:80
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62312 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM7
Chain IDs:DB (auth: 67)
Chain Length:103
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UK45 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U6 snRNA-associated Sm-like p
Gene (Uniprot):LSM8
Chain IDs:EB (auth: 68)
Chain Length:96
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O95777 Pfam ID:PF01423
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3A subunit 1
Gene (Uniprot):SF3A1
Chain IDs:E (auth: 7)
Chain Length:793
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15459 Pfam ID:PF01805, PF12230, PF00240
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3A subunit 2
Gene (Uniprot):SF3A2
Chain IDs:BA (auth: 8)
Chain Length:464
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15428 Pfam ID:PF12874, PF16835
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3A subunit 3
Gene (Uniprot):SF3A3
Chain IDs:AA (auth: 9)
Chain Length:501
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q12874 Pfam ID:PF12108, PF16837, PF13297, PF11931
Polymer Type:polypeptide(L)
Molecule:Pre-mRNA-processing-splicing
Chain IDs:A
Chain Length:2769
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Serine/arginine-rich splicing
Gene (Uniprot):SRSF1
Chain IDs:GB (auth: A6)
Chain Length:248
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q07955 Pfam ID:PF00076
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U5 small nuclear ribonucleopr
Gene (Uniprot):SNRNP200
Chain IDs:B
Chain Length:2136
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75643 Pfam ID:PF21188, PF18149, PF00270, PF00271, PF23445, PF02889 EC:3.6.4.13
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 1
Gene (Uniprot):SF3B1
Chain IDs:FA (auth: B1)
Chain Length:1304
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75533 Pfam ID:PF08920, PF22646
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 2
Gene (Uniprot):SF3B2
Chain IDs:CA (auth: B2)
Chain Length:895
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13435 Pfam ID:PF02037, PF04037, PF04046
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 3
Gene (Uniprot):SF3B3
Chain IDs:EA (auth: B3)
Chain Length:1217
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15393 Pfam ID:PF10433, PF23726, PF03178
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 4
Gene (Uniprot):SF3B4
Chain IDs:Z (auth: B4)
Chain Length:424
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15427 Pfam ID:PF00076
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 5
Gene (Uniprot):SF3B5
Chain IDs:DA (auth: B5)
Chain Length:86
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BWJ5 Pfam ID:PF07189
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Splicing factor 3B subunit 6
Gene (Uniprot):SF3B6
Chain IDs:GA (auth: B6)
Chain Length:125
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y3B4 Pfam ID:PF00076
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-catenin-like protein 1
Gene (Uniprot):CTNNBL1
Chain IDs:HA (auth: BL)
Chain Length:563
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8WYA6 Pfam ID:PF08216
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:116 kDa U5 small nuclear ribo
Gene (Uniprot):EFTUD2
Chain IDs:H (auth: C)
Chain Length:972
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15029 Pfam ID:PF16004, PF00009, PF03144, PF14492, PF03764, PF00679
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:ATP-dependent RNA helicase DH
Gene (Uniprot):DHX15
Chain IDs:JA (auth: DH)
Chain Length:795
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43143 Pfam ID:PF00270, PF00271, PF04408, PF21010, PF07717 EC:3.6.4.13
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U5 small nuclear ribonucleopr
Gene (Uniprot):SNRNP40
Chain IDs:I (auth: E)
Chain Length:357
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96DI7 Pfam ID:PF00400
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pleiotropic regulator 1
Gene (Uniprot):PLRG1
Chain IDs:J (auth: G)
Chain Length:514
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43660 Pfam ID:PF00400
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pre-mRNA-splicing factor 38A
Gene (Uniprot):PRPF38A
Chain IDs:K (auth: I)
Chain Length:312
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8NAV1 Pfam ID:PF03371, PF12871
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Microfibrillar-associated pro
Gene (Uniprot):MFAP1
Chain IDs:IB (auth: K)
Chain Length:439
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P55081 Pfam ID:PF06991
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cell division cycle 5-like pr
Gene (Uniprot):CDC5L
Chain IDs:G (auth: L)
Chain Length:802
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99459 Pfam ID:PF13921, PF11831
Polymer Type:polypeptide(L)
Molecule:Pre-mRNA-splicing factor RBM2
Chain IDs:PA (auth: P)
Chain Length:500
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pre-mRNA-processing factor 17
Gene (Uniprot):CDC40
Chain IDs:JB (auth: P7)
Chain Length:579
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O60508 Pfam ID:PF00400
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein BUD31 homolog
Gene (Uniprot):BUD31
Chain IDs:L (auth: Q)
Chain Length:144
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41223 Pfam ID:PF01125
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spliceosome-associated protei
Gene (Uniprot):CWC15
Chain IDs:M (auth: R)
Chain Length:229
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9P013 Pfam ID:PF04889
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:SNW domain-containing protein
Gene (Uniprot):SNW1
Chain IDs:FB (auth: S1)
Chain Length:536
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13573 Pfam ID:PF02731
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:U2 snRNP-associated SURP moti
Gene (Uniprot):U2SURP
Chain IDs:IA (auth: SR)
Chain Length:1029
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15042 Pfam ID:PF00076, PF01805, PF04818, PF08312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transcription elongation regu
Gene (Uniprot):TCERG1
Chain IDs:HB (auth: T)
Chain Length:1098
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O14776 Pfam ID:PF00397, PF23517, PF01846
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:WW domain-binding protein 11
Gene (Uniprot):WBP11
Chain IDs:N (auth: X)
Chain Length:641
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9Y2W2 Pfam ID:PF09429
Polymer Type:polyribonucleotide
Molecule:pre-mRNA
Chain IDs:KA (auth: Z)
Chain Length:410
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like protein 5
Gene (Uniprot):UBL5
Chain IDs:O (auth: q)
Chain Length:73
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9BZL1 Pfam ID:PF00240
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Zinc finger matrin-type prote
Gene (Uniprot):ZMAT2
Chain IDs:P (auth: r)
Chain Length:199
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96NC0 Pfam ID:PF12171
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:RING-type E3 ubiquitin-protei
Gene (Uniprot):PPIL2
Chain IDs:QA (auth: t)
Chain Length:520
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13356 Pfam ID:PF00160 EC:2.3.2.27
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:WD40 repeat-containing protei
Gene (Uniprot):SMU1
Chain IDs:NA (auth: v), OA (auth: w)
Chain Length:513
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q2TAY7 Pfam ID:PF17814, PF00400
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein Red
Gene (Uniprot):IK
Chain IDs:LA (auth: x), MA (auth: y)
Chain Length:557
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:Q13123 Pfam ID:PF07808, PF07807
Ligand Molecules
NA
Primary Citation
cryo-EM structure of the human pre-Bact-OTS complex
To Be Published ? ? ? (?)
Primary Citation of related structures
9R8V
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