ISDA: 9R3R

Deposition Date 2025-05-06

Release Date 2026-06-10

Last Version Date 2026-06-10

Entry Detail

PDB ID:

9R3R

Keywords:

LIGASE

Title:

CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Cryptosporidium parvum COMPLEXED WITH L-LYSINE AND INHIBITOR DDD01827593

Biological Source:

Source Organism(s):

Cryptosporidium parvum Iowa II (Taxon ID: 353152)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.50 Å

R-Value Free:

0.18

R-Value Work:

0.15

Space Group:

P 2 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Lysine--tRNA ligase
Gene (Uniprot):cgd4_2370
Chain IDs:A, B
Chain Length:535
Number of Molecules:2
Biological Source:Cryptosporidium parvum Iowa II

UniProt ID:Q5CR27 Pfam ID:PF01336, PF00152 EC:6.1.1.6

Ligand Molecules

A1JC9

LYS

SO4

Primary Citation

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites

Forte, B, Bellany, F, Campbell, P.S, Chemi, G, Dawson, A, Anderson, M, Aniweh, Y, Burkhard, A.Y, Aguiar, A.C.C, Churchyard, A, Cooper, C.A, dos Santos Ferreira, A, Famodimu, M.T, Fang, F.G, Hu, X, Huijs, T, Baud, D, Jansen, C, Jimenez Diaz, M.B, Bonnert, R, Boyd, S, Crespo-Fernandez, B, Mitasev, B, Montagna, S, Mok, S, Murugesan, D, Narwal, S.K, Norcross, N.R, Okombo, J, Park, H, Peet, C, Pereira, D.B, Post, J.M, Reader, J, Riley, J, Robinson, D.A, Shinkyo, R, Simeons, F.R, Simpson, L, Smith, A, Smith, D, Striepen, J, Teles, C.B, van der Laak, R, Uhlemann, A.C, Vantaux, A, Wilson, C, Witkowski, B, Wood, G, Yeo, T, Zuccotto, F, Angulo-Barturen, I, Baum, J, Bolscher, J.M, Guido, R.V.C, Birkholtz, L.M, Delves, M.J, Dembele, L, Fidock, D.A, Gamo, F.J, Kyle, D.E, Maher, S.P, Popovici, J, Walpole, C, Gusovsky, F, Willis, P.A, Read, K.D, Gilbert, I.H, Baragana, B.Show

J.Med.Chem. ? ? ? (2026)

DOI: 10.1021/acs.jmedchem.6c00823

Primary Citation of related structures

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