ISDA: 9R25

Deposition Date 2025-04-29

Release Date 2026-05-06

Last Version Date 2026-05-06

Entry Detail

PDB ID:

9R25

Keywords:

TRANSFERASE

Title:

Sorafenib in complex with p38alpha (MAPK14)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitogen-activated protein kin
Gene (Uniprot):MAPK14
Chain IDs:A
Chain Length:360
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q16539 Pfam ID:PF00069 EC:2.7.11.24

Ligand Molecules

BAX

BOG

Primary Citation

Sorafenib and regorafenib differentially impact the dynamic conformational ensemble of p38alpha

Gomez, S.M, Buehrmann, M, Klein, A, Vasa, S.K, Weisner, J, Vatheuer, H, Czodrowski, P, Rauh, D, Linser, R.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form