ISDA: 9R1C

Deposition Date 2025-04-26

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9R1C

Keywords:

PEPTIDE BINDING PROTEIN

Title:

Keap1 - inhibitor complex - 1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.69 Å

R-Value Free:

0.20

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Kelch-like ECH-associated pro
Gene (Uniprot):KEAP1
Chain IDs:A
Chain Length:414
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14145 Pfam ID:PF01344

Ligand Molecules

A1JB1

DMS

Primary Citation

Tetrazole-containing naphthalene bis-sulfonamide Keap1-Nrf2 interaction inhibitors with unexpected binding modes.

Georgakopoulos, N.D, Talapatra, S.K, Dayalan Naidu, S, Dikovskaya, D, Higgins, M, Gatliff, J, Nikoloudaki, R, Schaap, M, Walker, J.M, Wardby, C, Dinkova-Kostova, A.T, Harris, S, Kozielski, F, Wells, G.Show

Redox Biol 88 103924 103924 (2025)

PMID: 41242018 DOI: 10.1016/j.redox.2025.103924

Primary Citation of related structures

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