ISDA: 9QDW

Deposition Date 2025-03-07

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

9QDW

Keywords:

HYDROLASE

Title:

Crystal structure of human PLA2G5 in complex with a SMOL inhibitor (compound 1)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.49 Å

R-Value Free:

0.31

R-Value Work:

0.25

R-Value Observed:

0.26

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Phospholipase A2 group V
Chain IDs:A, B
Chain Length:120
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1I5M

Primary Citation

Identification of a XYZ Derivative (BAY XYZ) as a Potent and Selective Inhibitor of PLA2G5

Fearon, D, Puetter, V, Braeuer, N, Friberg, A, Barker, J.J, Schwede, W, Scott, J, Langer, G, Sacher, F.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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