ISDA: 9Q8R

Deposition Date 2025-02-25

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

9Q8R

Keywords:

TRANSFERASE

Title:

Human ROCK1 in complex with a dihydropyrazolo-pyrimidine inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.05 Å

R-Value Free:

0.28

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Rho-associated protein kinase
Gene (Uniprot):ROCK1
Chain IDs:A, B, C, D
Chain Length:402
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q13464 EC:2.7.11.1

Ligand Molecules

A1I40

Primary Citation

Discovery of a Selective Inhaled Rho Kinase Inhibitor with Therapeutic Effects in Experimental Pulmonary Hypertension

Edwards, C, Cantoni, S, Pala, D, Pasqua, E, Pastore, F, Rancati, F, Clark, D, Bhalay, G, Vaccaro, F, Riccardi, B, Fioni, A, Bassanetti, I, Pioselli, B, Patacchini, R, Facchinetti, F, Accetta, A.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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