9Q8G image
Deposition Date 2025-02-24
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9Q8G
Keywords:
RNA BINDING PROTEIN
Title:
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 4 / EP102
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.75 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 32 2 1
9Q8G validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N(6)-adenosine-methyltransfer
Gene (Uniprot):METTL3
Chain IDs:A
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q86U44 Pfam ID:PF05063 EC:2.1.1.348
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N(6)-adenosine-methyltransfer
Gene (Uniprot):METTL14
Chain IDs:B
Chain Length:279
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9HCE5 Pfam ID:PF05063 EC:2.1.1.348
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CSO A CYS modified residue
Ligand Molecules
A1I4I
Primary Citation
Optimization of METTL3 Inhibitors for the Treatment of Solid Tumors and AML
J. Med. Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c00474
Primary Citation of related structures
9IH5
9Q89
9Q8A
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