9IH5 image
Deposition Date 2025-02-20
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9IH5
Keywords:
RNA BINDING PROTEIN
Title:
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 8
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.85 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 32 2 1
9IH5 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N6-adenosine-methyltransferas
Gene (Uniprot):METTL3
Chain IDs:A
Chain Length:213
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q86U44 Pfam ID:PF05063 EC:2.1.1.348
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:N(6)-adenosine-methyltransfer
Gene (Uniprot):METTL14
Chain IDs:B
Chain Length:291
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9HCE5 Pfam ID:PF05063 EC:2.1.1.348
Ligand Molecules
A1I4E
Primary Citation
Optimization of METTL3 Inhibitors for the Treatment of Solid Tumors and AML
J. Med. Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c00474
Primary Citation of related structures
9IH5
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