ISDA: 9Q8D

Deposition Date 2025-02-24

Release Date 2026-03-11

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9Q8D

Keywords:

HYDROLASE

Title:

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.54 Å

R-Value Free:

0.21

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Monoglyceride lipase
Gene (Uniprot):MGLL
Chain IDs:A
Chain Length:323
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q99685 Pfam ID:PF12146 EC:3.1.1.23

Ligand Molecules

A1I4L

EDO

Primary Citation

Discovery of PET tracers using tritiated scaffolds at Roche on the specific example of optimizing a biomarker for brain-monoacylglycerol lipase inhibitors

Grether, U, Edelmann, M, Gobbi, L, Schmalzbauer, S, Beck, J, Mueller, M, Wittwer, M, Haider, A, Honer, M, Collin, L, Heer, D, Topp, A, Hilbert, M, Huber, S, Leibrock, L, Benz, J.Show

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Primary Citation of related structures

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