ISDA: 9Q6F

Deposition Date 2025-08-22

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9Q6F

Keywords:

HYDROLASE

Title:

Structure of Plasmodium falciparum 20S proteasome bound to an asparagine-ethylenediamine based inhibitor TDI6245

Biological Source:

Source Organism(s):

Plasmodium falciparum (Taxon ID: 5833)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.86 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_2446, CYL21_1296, PFNF54_02078
Chain IDs:A, O
Chain Length:260
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7JVP8 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_4966, CYL21_4378
Chain IDs:B, P
Chain Length:302
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:A0A2I0BQ13

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_4303, CYL21_5399, PFNF54_00272
Chain IDs:C, Q
Chain Length:246
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7KN95 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_4499, CYL21_5482
Chain IDs:D, R
Chain Length:241
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:A0A2I0BS43

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_5367, CYL21_5183
Chain IDs:E, S
Chain Length:256
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:A0A2I0BP34

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_0007, CYL21_2454, PFNF54_05872
Chain IDs:F, T
Chain Length:253
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7K5W7 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit alpha type
Gene (Uniprot):CK202_3814, CYL21_3097, PFNF54_00518
Chain IDs:G, U
Chain Length:252
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7K040 Pfam ID:PF10584, PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta type-
Gene (Uniprot):CK202_4201, CYL21_1069, PFNF54_02629
Chain IDs:H, V
Chain Length:252
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7JUG8 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_2690, CYL21_4000, PFNF54_04378
Chain IDs:I, W
Chain Length:229
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7K1J4 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_2185, CYL21_3554
Chain IDs:J, X
Chain Length:218
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:A0A2I0BXS0

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_0043, CYL21_2079, PFNF54_05825
Chain IDs:K, Y
Chain Length:195
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7JKG5 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_4752, CYL21_3663, PFNF54_02809
Chain IDs:L, Z
Chain Length:211
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7K6A8 Pfam ID:PF00227

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_3362, CYL21_3125
Chain IDs:M, AA (auth: a)
Chain Length:260
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:A0A2I0BU46

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proteasome subunit beta
Gene (Uniprot):CK202_2268, CYL21_1305, PFNF54_02044
Chain IDs:N, BA (auth: b)
Chain Length:302
Number of Molecules:2
Biological Source:Plasmodium falciparum

UniProt ID:W7K6I2 Pfam ID:PF00227

Ligand Molecules

A1CRS

Primary Citation

Structure-activity relationship study of antimalarial asparagine derived proteasome inhibitors

Zhang, H, Hsu, H.C, Zhan, W, Hara, R, Visone, J, Imaeda, T, Okamoto, R, Fajtova, P, Sato, K, Michino, M, Garg, S, Kreutzfeld, O, Tumwebaze, P, Orena, S, Okitwi, M, Aso, K, Cooper, R, Rosenthal, P.J, Meinke, P.T, Foley, M, ODonoghue, A.J, Li, H, Kirkman, L.A, Lin, G.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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