ISDA: 9Q60

Deposition Date 2025-08-21

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9Q60

Keywords:

IMMUNE SYSTEM

Title:

CryoEM Structure of human MDA5 disease-linked mutant T331I with dsRNA (one protein subunit on dsRNA)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag', In vitro transcription vector pt7-fluc(deltai)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.12 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:RNA-13mer
Chain IDs:C (auth: A)
Chain Length:13
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polyribonucleotide
Molecule:RNA-13mer
Chain IDs:B
Chain Length:13
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Interferon-induced helicase C
Mutagens:T331I
Chain IDs:A (auth: C)
Chain Length:728
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

ATP

Primary Citation

Unraveling the molecular basis for MDA5 T331I disease-linked mutation

Xu, L, Chung, K, Guo, R, Pan, A, Pyle, A.M.Show

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