ISDA: 9PXH

Deposition Date 2025-08-05

Release Date 2026-09-02

Last Version Date 2026-09-23

Entry Detail

PDB ID:

9PXH

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of bovine ALDH3A1 in complex with Non-Canonical Redox Cofactors, NMN+

Biological Source:

Source Organism(s):

Bos taurus (Taxon ID: 9913)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.77 Å

R-Value Free:

0.20

R-Value Work:

0.15

R-Value Observed:

0.15

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aldehyde dehydrogenase
Chain IDs:A, B, C, D
Chain Length:452
Number of Molecules:4
Biological Source:Bos taurus

Ligand Molecules

EDO

FMT

GOL

NMN

PGE

Primary Citation

A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.

Saleh, S, Hsu, N.H, Luu, E, Martin, V.C, Ng, H.J.C, Black, W.B, Zhang, S, Kim, J.K, Sankaran, B, Tran, A.H.T, Hayes, R.L, Siegel, J.B, Qiao, F, Li, H.Show

Nat.Chem.Biol. ? ? ? (2026)

PMID: 42717052 DOI: 10.1038/s41589-026-02315-w

Primary Citation of related structures

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