9PUT image
Deposition Date 2025-07-31
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9PUT
Title:
HRAS complex with UM0152535 compound
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.00 Å
R-Value Free:
0.23
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
C 1 2 1
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:GTPase HRas
Gene (Uniprot):HRAS
Chain IDs:A, B (auth: C)
Chain Length:167
Number of Molecules:2
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:UM0152535
Chain IDs:C (auth: B), D
Chain Length:11
Number of Molecules:2
Biological Source:synthetic construct
Primary Citation
Targeting the H/KRAS alpha 4-beta 6-alpha 5 Allosteric Lobe with Macrocyclic Peptides
Acs Med.Chem.Lett. ? ? ? (2026)
DOI: 10.1021/acsmedchemlett.6c00078
Primary Citation of related structures
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