9PUQ image
Deposition Date 2025-07-31
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9PUQ
Keywords:
HYDROLASE/INHIBITOR
Title:
HRAS complex with UM0152248 compound
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.00 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.20
Space Group:
P 21 21 21
9PUQ validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:GTPase HRas
Gene (Uniprot):HRAS
Chain IDs:A, B, C
Chain Length:166
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P01112 Pfam ID:PF00071 EC:3.6.5.2
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:UM0152248
Chain IDs:D
Chain Length:10
Number of Molecules:1
Biological Source:synthetic construct
UniProt ID:9PUQ
Ligand Molecules
GDP
MG
Primary Citation
Targeting the H/KRAS alpha 4-beta 6-alpha 5 Allosteric Lobe with Macrocyclic Peptides
Acs Med.Chem.Lett. ? ? ? (2026)
DOI: 10.1021/acsmedchemlett.6c00078
Primary Citation of related structures
9PUQ
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