ISDA: 9PU5

Deposition Date 2025-07-30

Release Date 2026-05-27

Last Version Date 2026-05-27

Entry Detail

PDB ID:

9PU5

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human MOR-Gi1 complex protein bound with DAMGO and BMS986187

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:S47N, G203A, E245A, A326S
Chain IDs:A, F (auth: B)
Chain Length:354
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503 EC:3.6.5.-

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B (auth: D), G (auth: C)
Chain Length:342
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G), H (auth: E)
Chain Length:80
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mu-type opioid receptor
Gene (Uniprot):OPRM1
Chain IDs:D (auth: R), I (auth: F)
Chain Length:388
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P35372 Pfam ID:PF00001

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DAMGO
Chain IDs:E (auth: S), J (auth: H)
Chain Length:5
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules