9PU3 image
Deposition Date 2025-07-30
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
9PU3
Keywords:
HYDROLASE/INHIBITOR
Title:
HRAS complex with UM0140692 compound
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.70 Å
R-Value Free:
0.21
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
C 1 2 1
9PU3 validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:GTPase HRas
Gene (Uniprot):HRAS
Chain IDs:A
Chain Length:166
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01112 Pfam ID:PF00071 EC:3.6.5.2
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:UM0140692
Chain IDs:B (auth: C)
Chain Length:10
Number of Molecules:1
Biological Source:synthetic construct
UniProt ID:9PU3
Ligand Molecules
GDP
MG
Primary Citation
Targeting the H/KRAS alpha 4-beta 6-alpha 5 Allosteric Lobe with Macrocyclic Peptides
Acs Med.Chem.Lett. ? ? ? (2026)
DOI: 10.1021/acsmedchemlett.6c00078
Primary Citation of related structures
9PU3
Feedback Form
Name
Email
Institute
Feedback