9PTT image
Deposition Date 2025-07-29
Release Date 2026-11-04
Last Version Date 2026-11-04
Entry Detail
PDB ID:
9PTT
Title:
Protein Complex(local refinement)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Frizzled-4
Gene (Uniprot):FZD4
Chain IDs:A, F (auth: C)
Chain Length:537
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Tetraspanin-12
Gene (Uniprot):TSPAN12
Chain IDs:B, G (auth: D)
Chain Length:305
Number of Molecules:2
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Norrin
Gene (Uniprot):NDP
Chain IDs:C (auth: M), E (auth: H), H (auth: F), J (auth: G)
Chain Length:133
Number of Molecules:4
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Low-density lipoprotein recep
Gene (Uniprot):LRP5
Chain IDs:D (auth: P), I (auth: K)
Chain Length:1615
Number of Molecules:2
Biological Source:Homo sapiens
Primary Citation
Architecture of the Norrin signaling complex and structure-guided surrogate design.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42907587 DOI: 10.1038/s41594-026-01909-1
Primary Citation of related structures
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