9PPZ image
Deposition Date 2025-07-22
Release Date 2026-03-04
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9PPZ
Keywords:
MEMBRANE PROTEIN
Title:
CryoEM structure of delta opioid receptor bound to G proteins and SNC80
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.19 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9PPZ validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Delta-type opioid receptor
Gene (Uniprot):OPRD1
Chain IDs:A
Chain Length:303
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P41143 Pfam ID:PF00001
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:S47N, G203A, E245A, A326S
Chain IDs:B
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63096 Pfam ID:PF00503
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C
Chain Length:340
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D
Chain Length:71
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Polymer Type:polypeptide(L)
Molecule:ScFv16 protein
Chain IDs:E
Chain Length:251
Number of Molecules:1
Biological Source:Mus musculus
Ligand Molecules
A1CLI
Primary Citation
Mechanistic insights into the therapeutic properties of delta opioid receptor.
Sci Adv 12 eaeb6737 eaeb6737 (2026)
PMID: 41880505 DOI: 10.1126/sciadv.aeb6737
Primary Citation of related structures
9PPZ
Feedback Form
Name
Email
Institute
Feedback