9PNC image
Deposition Date 2025-07-19
Release Date 2026-07-22
Last Version Date 2026-11-11
Entry Detail
PDB ID:
9PNC
Keywords:
HYDROLASE
Title:
Crystal structure of human mitochondrial ClpP protease C144R mutant in complex with imipridone compound, TR-65
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.70 Å
R-Value Free:
0.27
R-Value Work:
0.23
R-Value Observed:
0.23
Space Group:
C 1 2 1
9PNC validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):CLPP
Mutagens:C144R
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N
Chain Length:221
Number of Molecules:14
Biological Source:Homo sapiens
UniProt ID:Q16740 Pfam ID:PF00574 EC:3.4.21.92
Ligand Molecules
PJF
Primary Citation
Identification of substrates of the human mitochondrial ClpXP protease and its implications for Perrault syndrome.
Nat Commun 17 ? ? (2026)
PMID: 42928091 DOI: 10.1038/s41467-026-77888-0
Primary Citation of related structures
9PNC
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