ISDA: 9PNC

Deposition Date 2025-07-19

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9PNC

Keywords:

HYDROLASE

Title:

Crystal structure of human mitochondrial ClpP protease C144R mutant in complex with imipridone compound, TR-65

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.27

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):CLPP
Mutagens:C144R
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N
Chain Length:221
Number of Molecules:14
Biological Source:Homo sapiens

UniProt ID:Q16740 Pfam ID:PF00574 EC:3.4.21.92

Ligand Molecules

PJF

Primary Citation

A molecular basis for Perrault syndrome type 3 and the identification of novel substrates of the mitochondrial ClpXP protease

Houry, W.A, Mabanglo, M.F.Show

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Primary Citation of related structures

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