ISDA: 9PI6

Deposition Date 2025-07-10

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

9PI6

Keywords:

DNA BINDING PROTEIN

Title:

Single stranded DNA-binding protein (ICP8) from Herpes simplex virus-1, apo form.Mutations: K166A, E167A, C254S, C455S

Biological Source:

Source Organism(s):

Human alphaherpesvirus 1 (Taxon ID: 10298)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.75 Å

R-Value Free:

0.26

R-Value Work:

0.17

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Major DNA-binding protein
Mutagens:K166A, E167A, C254S, C455S
Chain IDs:A, B
Chain Length:1136
Number of Molecules:2
Biological Source:Human alphaherpesvirus 1

Ligand Molecules

GOL

SO4

Primary Citation

The crystal structure of the herpes virus ICP8 protein in complex with single-stranded DNA reveals the molecular determinants of nucleotide recognition.

Erlandsen, H, Krucinska, J, Wilderman, P.R, Makkay, A.M, Szczepaniak, R, Wright, L.R, Weller, S.K, Wright, D.L.Show

J. Biol. Chem. ? 111366 111366 (2026)

PMID: 41833734 DOI: 10.1016/j.jbc.2026.111366

Primary Citation of related structures

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