ISDA: 9PEA

Deposition Date 2025-07-01

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9PEA

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of full-length human TRPV1 in complex with analgesic MSP20

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transient receptor potential
Gene (Uniprot):TRPV1
Chain IDs:A, B, C, D
Chain Length:1102
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q8NER1 Pfam ID:PF12796, PF00023, PF00520

Ligand Molecules

A1CHV

CLR

POV

TRD

Primary Citation

Design, synthesis and structural mechanism of action of TRPV1 agonist MSP20 with long-lasting analgesic effect.

Neuberger, A, Romeo, I, Aiello, F, Alekseev, A, Maramai, S, Pessina, F, Vagaggini, C, Poggialini, F, Dreassi, E, Frosini, M, Schiano Moriello, A, De Petrocellis, L, Morace, A.M, Belardo, C, Perrone, M, Bonsale, R, Luongo, L, Maione, S, Talyzina, I.A, Alcaro, S, Artese, A, Brizzi, A, Sobolevsky, A.I.Show

Nat Commun ? ? ? (2026)

PMID: 42409805 DOI: 10.1038/s41467-026-74972-3

Primary Citation of related structures

Feedback Form