ISDA: 9P1V

Deposition Date 2025-06-10

Release Date 2026-06-17

Last Version Date 2026-06-17

Entry Detail

PDB ID:

9P1V

Keywords:

ANTIMICROBIAL PROTEIN

Title:

Structure of MAb PhtD3 in complex with PhtD

Biological Source:

Source Organism(s):

Streptococcus pneumoniae (Taxon ID: 1313)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.27 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histidine triad protein D
Gene (Uniprot):phtD
Chain IDs:A
Chain Length:838
Number of Molecules:1
Biological Source:Streptococcus pneumoniae

UniProt ID:A0A0E3JFL0

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MAb PhtD3 antibody heavy chai
Chain IDs:C (auth: H)
Chain Length:474
Number of Molecules:1
Biological Source:Homo sapiens

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MAb PhtD3 antibody light chai
Chain IDs:B (auth: L)
Chain Length:235
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Fc-engineering and structural characterization of a broadly reactive monoclonal antibody targeting the pneumococcal histidine triad protein D (PhtD) on the surface of Streptococcus pneumoniae

Eisenhauer, J, Gingerich, A.D, Du, J, Parzych, E.M, Li, Y, McCormick, A.L, Lin, Z.J, Cui, J, Cassel, J, Bhardwaj, B, Chu, J.D, Smith, T, Patel, A, Mousa, J.J, Pallesen, J, Weiner, D.B.Show

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Primary Citation of related structures

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