ISDA: 9OT5

Deposition Date 2025-05-26

Release Date 2026-06-24

Last Version Date 2026-06-24

Entry Detail

PDB ID:

9OT5

Keywords:

VIRAL PROTEIN/INHIBITOR

Title:

SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor E2

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.24

R-Value Work:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Chain IDs:A, B
Chain Length:306
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules

A1CD8

DMS

PEG

Primary Citation

SARS-CoV-2 Main Protease (Mpro) in Complex with Covalent Inhibitor E2

Mazzorana, M, Oliveira Borges, P.H, Silva-Junior, F, Baptista Ferreira, S, Walsh, M.A.Show

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Primary Citation of related structures

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