ISDA: 9OSL

Deposition Date 2025-05-24

Release Date 2026-06-03

Last Version Date 2026-06-03

Entry Detail

PDB ID:

9OSL

Keywords:

LIGASE

Title:

Crystal structure of the transpeptidase domain of a Y422A mutant of PBP2 from Neisseria gonorrhoeae strain H041 acylated by ceftriaxone

Biological Source:

Source Organism(s):

Neisseria gonorrhoeae (Taxon ID: 485)

Expression System(s):

Escherichia coli k-12

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.40 Å

R-Value Free:

0.24

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable peptidoglycan D,D-tr
Gene (Uniprot):penA
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Neisseria gonorrhoeae

UniProt ID:F2Z7K9 EC:3.4.16.4

Ligand Molecules

CEF

GOL

PGE

Primary Citation

Tyrosine-422 plays a crucial role in acylation and transpeptidation in penicillin-binding protein 2 from Neisseria gonorrhoeae

Stratton, C.M, Bala, S, Bivins, M.M, Nicholas, R.A, Davies, C.Show

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Primary Citation of related structures

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