ISDA: 9OS3

Deposition Date 2025-05-23

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

9OS3

Keywords:

OXIDOREDUCTASE

Title:

Human DHODH in complex with ligand H3D2856

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.21

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 32 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydroorotate dehydrogenase
Gene (Uniprot):DHODH
Chain IDs:A
Chain Length:368
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q02127 EC:1.3.5.2

Ligand Molecules

A1C4U

DMS

FMN

GOL

ORO

SO4

Primary Citation

Targeting HsDHODH: Shape and machine-learning guided discovery and structural validation of SARS-CoV-2 antivirals.

Cruz, L.V, Silva-Mendonca, S, da Purificacao, A.D, Mottin, M, Arbelaez, M, Freitas, C.S, Fintelman-Rodrigues, N, Mattos, M, Froes, T.Q, Jurisch, C.D, Seanego, D, Boyle, G.A, Campos, F.F.G.R, Souza, T.M.L, Gessner, R.K, Chibale, K, Nonato, M.C, Andrade, C.H.Show

Eur.J.Med.Chem. 317 119123 119123 (2026)

PMID: 42435557 DOI: 10.1016/j.ejmech.2026.119123

Primary Citation of related structures

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