9OPQ image
Deposition Date 2025-05-19
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9OPQ
Keywords:
VIRAL PROTEIN/HYDROLASE
Title:
TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD
Biological Source:
Source Organism(s):
Human coronavirus HKU1 (Taxon ID: 290028)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OPQ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:NL63-S2prime/HKU1-RBD
Gene (Uniprot):S
Chain IDs:A
Chain Length:376
Number of Molecules:1
Biological Source:Human coronavirus HKU1
UniProt ID:Q5MQD0
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transmembrane protease serine
Gene (Uniprot):TMPRSS2
Mutagens:S441A
Chain IDs:B
Chain Length:506
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O15393 Pfam ID:PF15494, PF00089 EC:3.4.21.B60
Ligand Molecules
NAG
Primary Citation
TMPRSS2-mediated coronavirus spike activation and inhibition.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42050172 DOI: 10.1038/s41594-026-01801-y
Primary Citation of related structures
9OPR
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