9OPR image
Deposition Date 2025-05-19
Release Date 2026-05-13
Last Version Date 2026-05-13
Entry Detail
PDB ID:
9OPR
Keywords:
HYDROLASE/IMMUNE SYSTEM
Title:
TMPRSS2 S441A in complex with the H1H7 Fab and anti-kappa light chain nanobody
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
Expression System(s):
Homo sapiens, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OPR validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Transmembrane protease serine
Gene (Uniprot):TMPRSS2, SMT3
Mutagens:S441A
Chain IDs:A
Chain Length:533
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q12306,O15393 Pfam ID:PF00240, PF15494, PF00089 EC:3.4.21.B60
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:H1H7 antibody heavy chain
Chain IDs:B (auth: H)
Chain Length:220
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:9OPR
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:H1H7 antibody light chain
Chain IDs:C (auth: L)
Chain Length:212
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:9OPR
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:anti-kappa light chain nanobo
Chain IDs:D (auth: N)
Chain Length:159
Number of Molecules:1
Biological Source:Lama glama
UniProt ID:9OPR
Primary Citation
TMPRSS2-mediated coronavirus spike activation and inhibition.
Nat.Struct.Mol.Biol. ? ? ? (2026)
PMID: 42050172 DOI: 10.1038/s41594-026-01801-y
Primary Citation of related structures
9OPR
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