9OGO image
Deposition Date 2025-05-01
Release Date 2025-11-26
Last Version Date 2026-07-22
Entry Detail
PDB ID:
9OGO
Keywords:
TRANSPORT PROTEIN
Title:
Crystal Structure of KPT185 in complex with CRM1(EH mutant)-Ran-RanBP1
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Saccharomyces cerevisiae (Taxon ID: 4932)
Saccharomyces cerevisiae (Taxon ID: 559292)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.37 Å
R-Value Free:
0.23
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
P 43 21 2
9OGO validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:GTP-binding nuclear protein R
Gene (Uniprot):RAN
Chain IDs:A
Chain Length:237
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62826 Pfam ID:PF00071
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ran-specific GTPase-activatin
Gene (Uniprot):YRB1
Chain IDs:B
Chain Length:143
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
UniProt ID:P41920 Pfam ID:PF00638
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Exportin-1
Gene (Uniprot):CRM1
Mutagens:V529E, T539C, F572H, Y1022C
Chain IDs:C
Chain Length:1024
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
UniProt ID:P30822 Pfam ID:PF03810, PF08389, PF18777, PF18784, PF18787, PF08767
Ligand Molecules
CL
GNP
GOL
K85
MG
Primary Citation
SINE compounds activate exportin 1 degradation through an allosteric mechanism.
Nat.Chem.Biol. 21 2002 2013 (2025)
PMID: 41286136 DOI: 10.1038/s41589-025-02058-0
Primary Citation of related structures
9OGD
Feedback Form
Name
Email
Institute
Feedback