ISDA: 9OGD

Deposition Date 2025-04-30

Release Date 2025-11-26

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9OGD

Keywords:

PROTEIN TRANSPORT

Title:

Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to human ASB8(R197A)-ELOB/C

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.49 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Exportin-1
Gene (Uniprot):XPO1
Chain IDs:A
Chain Length:1073
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O14980 Pfam ID:PF03810, PF08389, PF18777, PF18784, PF18787, PF08767

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ankyrin repeat and SOCS box p
Gene (Uniprot):ASB8
Mutagens:R197A
Chain IDs:B
Chain Length:274
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H765 Pfam ID:PF12796, PF07525

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongin-C
Gene (Uniprot):ELOC
Chain IDs:C (auth: E)
Chain Length:97
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15369 Pfam ID:PF03931

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongin-B
Gene (Uniprot):ELOB
Chain IDs:D (auth: F)
Chain Length:118
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15370 Pfam ID:PF00240

Ligand Molecules