9OCJ image
Deposition Date 2025-04-24
Release Date 2025-09-10
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9OCJ
Title:
Transporter associated with antigen processing (TAP) bound to the viral protein CPXV012 in the outward-facing open state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Cowpox virus (Taxon ID: 10243)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.00 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 1
Gene (Uniprot):TAP1
Chain IDs:C (auth: A)
Chain Length:907
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 2
Gene (Uniprot):TAP2
Mutagens:E632Q
Chain IDs:A (auth: B)
Chain Length:686
Number of Molecules:1
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:TAP transporter inhibitor CPX
Gene (Uniprot):CPXV012 CDS
Chain IDs:B (auth: D)
Chain Length:123
Number of Molecules:1
Biological Source:Cowpox virus
Primary Citation
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP.
Proc. Natl. Acad. Sci. U.S.A. 122 e2516676122 e2516676122 (2025)
PMID: 40956880 DOI: 10.1073/pnas.2516676122
Primary Citation of related structures
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