9OCH image
Deposition Date 2025-04-24
Release Date 2025-09-10
Last Version Date 2026-03-18
Entry Detail
PDB ID:
9OCH
Keywords:
MEMBRANE PROTEIN
Title:
Transporter associated with antigen processing (TAP) bound to the viral protein hUS6 in the outward-facing open state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Human betaherpesvirus 5 (Taxon ID: 10359)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9OCH validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 1
Gene (Uniprot):TAP1
Chain IDs:C (auth: A)
Chain Length:887
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03518 Pfam ID:PF00664, PF00005 EC:7.4.2.14
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antigen peptide transporter 2
Gene (Uniprot):TAP2
Chain IDs:A (auth: B)
Chain Length:686
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03519 Pfam ID:PF00664, PF00005 EC:7.4.2.14
Protein Blast
Polymer Type:polypeptide(L)
Molecule:TAP transport inhibitor US6
Gene (Uniprot):US6
Chain IDs:B (auth: D)
Chain Length:239
Number of Molecules:1
Biological Source:Human betaherpesvirus 5
UniProt ID:P14334,D2K4Q9 Pfam ID:PF17616
Ligand Molecules
ADP
ATP
MG
Primary Citation
Structurally diverse viral inhibitors converge on a shared mechanism to stall the antigen transporter TAP.
Proc. Natl. Acad. Sci. U.S.A. 122 e2516676122 e2516676122 (2025)
PMID: 40956880 DOI: 10.1073/pnas.2516676122
Primary Citation of related structures
9OCH
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