9OBD image
Deposition Date 2025-04-22
Release Date 2026-04-29
Last Version Date 2026-04-29
Entry Detail
PDB ID:
9OBD
Keywords:
HYDROLASE
Title:
Crystal structure of human Argonaute2 in complex with a fully modified siRNA with a 5'-phenylpropargyl phosphate
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.02 Å
R-Value Free:
0.26
R-Value Work:
0.23
R-Value Observed:
0.23
Space Group:
P 1 21 1
9OBD validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein argonaute-2
Gene (Uniprot):AGO2
Mutagens:S387D S824A S828D S831D S834A
Chain IDs:A
Chain Length:859
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UKV8
Polymer Type:polyribonucleotide
Molecule:fully modified siRNA with a 5
Chain IDs:B
Chain Length:21
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
IPA
IPH
MG
Primary Citation
Discovery of Argonaute2 compatible 5'-Alkylated phosphate stabilization chemistry for siRNA guide strand
To Be Published ? ? ? (?)
Primary Citation of related structures
9OBD
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