ISDA: 9O6R

Deposition Date 2025-04-14

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9O6R

Keywords:

DNA BINDING PROTEIN

Title:

Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH2.29-LE

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.87 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

H 3

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Proliferating cell nuclear an
Gene (Uniprot):PCNA
Chain IDs:A, B, C, D
Chain Length:261
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P12004 Pfam ID:PF00705, PF02747

Ligand Molecules

XEU

Primary Citation

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

Haratipour, P, Zangi, M, Gu, L, Li, C.M, Yaghoubi, M, Jossart, J, Lingeman, R.G, Aris, K.L, Wendel, S, Meng, F, Xia, F, Azmi, A.S, Synold, T.W, Raoof, M, Wallace, N, Perry, J.J.P, Malkas, L.H, Hickey, R.J.Show

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Primary Citation of related structures

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