ISDA: 9O6J

Deposition Date 2025-04-13

Release Date 2026-02-25

Last Version Date 2026-09-09

Entry Detail

PDB ID:

9O6J

Keywords:

IMMUNE SYSTEM

Title:

Structure of Siglec-10 in complex with 2,3-Sialyllactose

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.39 Å

R-Value Free:

0.29

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 65 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sialic acid-binding Ig-like l
Gene (Uniprot):SIGLEC10
Chain IDs:A, B, C (auth: D)
Chain Length:219
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:Q96LC7 Pfam ID:PF07686

Ligand Molecules

NAG

SIA

Primary Citation

Structural basis for sialoglycan recognition by the immune inhibitory receptor Siglec-10.

Medina, E, Mason, C, Tran, T.H, Julia, E.P, Ming, Q, Taibi, L.M, Hwu, P, Maute, R.L, Burg, J.S, Luca, V.C.Show

Structure 34 768 777.e5 (2026)

PMID: 41747717 DOI: 10.1016/j.str.2026.01.018

Primary Citation of related structures

Feedback Form