ISDA: 9O47

Deposition Date 2025-04-08

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

9O47

Keywords:

RNA

Title:

RNA dodecamer containing a serinol nucleic acid.

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.22

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:Chains: A,B
Chain IDs:A, B
Chain Length:12
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

5BU

5GP

A1B9T

C5P

Primary Citation

Acyclic serinol nucleic acid (SNA) modification of siRNAs to overcome seed region mediated off-target effect of RNAi therapeutics while maintaining potency

Chickering, T, O'Flaherty, D.K, Harp, J.M, He, G, Theile, C.S, Qin, J, Hyde, S, Szeto, J, Janas, M, Jiang, Y, Charisse, K, Maier, M.A, Manoharan, M, Egli, M, Schlegel, M.K.Show

To be published ? ? ? (?)

Primary Citation of related structures

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