ISDA: 9NYP

Deposition Date 2025-03-28

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9NYP

Keywords:

TRANSLOCASE

Title:

Cryo-EM structure of NVL bound the the MM927 inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
unidentified (Taxon ID: 32644)

Expression System(s):

Escherichia coli bl21(de3), Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.86 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Nuclear valosin-containing pr
Gene (Uniprot):NVL
Mutagens:E366Q,E683Q
Chain IDs:A, B, C, D, E, F
Chain Length:856
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:O15381

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:polypeptide substrate mimic
Chain IDs:G (auth: P)
Chain Length:24
Number of Molecules:1
Biological Source:unidentified

UniProt ID:9NYP

Ligand Molecules

A1B7F

ADP

ATP

Primary Citation

Optimized dibenzothiazepinones activate the impaired ribosome biogenesis checkpoint and trigger p53-dependent apoptosis by inhibiting the 60S assembly factor NVL

Guo, H.H, Tao, Y, Cruz, V.E, Fang, M, Khivansara, V, Xie, S, Leach, A, Rivera-Cancel, G, Barrows, N, Williams, N, Aurora, A, Erzberger, J.P, De Brabander, J.K, Nijhawan, D.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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